• Research Title: Effect of Soy Protein Isolate Preload on Postprandial Glycemic Control in Healthy Humans

Researchers: Hideaki Kashima Ph.D., Saori Uemoto B.N.S., KoheiEguchi M.N.S., Masako Yamaoka Endo Ph.D., Akira Miura Ph.D., Toshio Kobayshi Ph.D. M.D., Yoshiyuki Fukuba Ph.D.


  • Soy protein isolate consumption before oral glucose tolerance test (as a simulated carbohydrate-rich main meal) improves postprandial glycemia.

  • Soy protein isolate preload enhanced the insulinotropic effect in a dose-dependent manner.

  • This positive effect could be induced by not only stimulating insulin secretion but also by possibly slowing gastric emptying.

  • Research Title: Soy Isoflavones Improve Insulin Sensitivity Without Changing Serum Leptin Among Postmenopausal Women

Researchers: P. Llaneza,C. González,J. Fernández-Iñarrea,A. Alonso,F. Díaz &F. R. Pérez-López


  • Diet, physical exercise and a daily oral intake of soy isoflavones exerted a beneficial effect on the homeostatic model in postmenopausal women which was not related to significant changes in plasma leptin levels, despite a decrease in TNF-α, fat mass and Kupperman values.

  • Research Title: Dietary Isoflavone Intake is Associated with Evoked Responses to Inflammatory Cardiometabolic Stimuli and Improved Glucose Homeostasis in Healthy Volunteers

Researchers: J F Ferguson, M F Ryan, E R Gibney, L Brennan, H M Roche, M P Reilly


  • Demonstrate that soy consumption may influence inflammatory and metabolic responses. In research of nutritional exposures, measuring evoked phenotypes may be more informative than describing resting characteristics. The GENE Study was registered under NCT00953667 and the MECHE Study under NCT01172951, both at clinicaltrials.gov.

  • Research Title: Effects of Soybean Peptide on Immune Function, Brain Function, and Neurochemistry in Healthy Volunteers

Researchers: Dilshat Yimit M.D., Ph.D., Parida Hoxur M.D., Ph.D., Nurmuhammat Amat M.D., Ph.D., Kimono Uchikawad, Nobuo Yamaguchi M.D., Ph.D.


  • Soybean peptides can modulate cellular immune systems, regulate neurotransmitters, and boost brain function.

  • The researchers analysed blood samples from healthy adults who regularly consumed soy peptides to determine the levels of immune cells and hormones. They also measured the blood flow in the brains of these volunteers to gauge how well their brains were functioning.

  • The volunteers displayed higher immune cell counts and improved hormone levels (leading to better mood overall) compared to individuals who did not regularly consume soy peptides. There was also more blood flowing through their brains, indicating increased brain function.

  • Research Title: Soy Protein Supplementation Reduces Clinical Indices For Blood Glucose and Metabolic Syndrome

Researchers: Bin Yang MSc, Ying Chen MSc, Tongchen Xu PhD, Yinghua Yu PhD, Tao Huang PhD, Xiaojie Hu MSc1, Duo Li PhD


  • The researchers reviewed 11 randomized controlled trials* that had previously explored the effects of soy peptide consumption on individuals with high blood sugar. After studying the literature, they concluded that soy peptide consumption helped with reducing blood glucose levels, regulating metabolism, decreasing inflammation, and bringing down the risk of kidney failure.

The long-term consumption of soy protein supplements (6 months or longer):

  • Reduces blood sugar levels

  • Lowers insulin levels

  • Improves metabolism

  • Decrease inflammation

  • Reduces risk of kidney failure

*In randomized controlled trials, study subjects are divided into two groups: one will receive the supplement and the other will receive a placebo. None of the participants know exactly what they are getting, which eliminates the risk of bias. The researchers in direct contact with the participants are also not informed to prevent them from unconsciously influencing the patients. This increases the accuracy and reliability of the study.

Disclaimer: Please note that the information provided is for educational and communications purposes only and should not be construed as personal medical advice. This information is not intended to replace, supplant or augment consultation with a health professional regarding the reader's own medical care. Statements regarding dietary supplements are not intended to diagnose, treat, cure, or prevent any disease or health condition. Hiramino disclaims all responsibility for any losses, damage to property or personal injury suffered directly or indirectly from reliance on such information.